Louis Guingot entered the École des Beaux-Arts and the École des Arts Décoratifs in Paris in 1880. Back in Nancy around 1895, he frequented the Nancy art scene. Trained as a painter, he specialized in  mural decoration for public buildings (Verdun, Vittel, Amiens, Charmes, Nancy) and religious buildings (Vaubexy, Haraucourt, Jeanménil): in 1899, he produced a series of eight paintings for the Thiers restaurant-brasserie (including six illustrating the story of Gargantua) and decorated the portico of the Palais des Fêtes at the 1909 International Exhibition in Nancy. Almost all of these murals have disappeared, and we know of his work only through old photographs.

As a decorator, he collaborated with René Wiener on the creation of bookbindings and worked on the development of new decorative processes on fabrics, hangings and plush.

During the First World War, he is credited with helping to invent of the camouflage military uniform with Jean-Baptiste Eugène Corbin.

Louis Guingot was a member of the École de Nancy steering committee from 1901.